For providers, 2017 is a critical transition year to CMS’s Merit-Based Incentive Payment System (MIPS) under MACRA, a primary driver of delivery system reform. Meaningful Use (MU) requirements are now folded into MIPS and providers must meet Stage 3 MU requirements starting in 2018. Much of the attention regarding regulation has been focused on electronic health records (EHRs) and information exchange platforms, but the future of information sharing focuses on public health reporting requiring the use of another critical asset: specialty registries. Specialty registries—available through public health agencies, national specialty societies, patient safety organizations or quality improvement organizations—have a distinct role in healthcare. Rather than collect data at the patient level, specialty registries aggregate detailed data from multiple sources regarding patients' specific diseases or conditions, like diabetes, Alzheimer's and breast cancer. Whereas EHRs are focused on individual patients at the point-of-care and exchanging information to enhance care, specialty registries are focused on tracking, measuring and improving outcomes for specific populations over time. They increase health professionals' knowledge and understanding about a particular condition, help providers design better treatment plans and assist in building targeted population health programs.