This is the time of year when many experts publish health information technology (HIT) trends and predictions, and 2019 has been no different. Artificial intelligence (AI), machine learning, blockchain technology, and voice applications have all featured prominently in these predictions.1 I wholeheartedly agree that these health technologies and applications are garnering significant investment and industry focus. It is indeed exciting to think about applying AI to generate actionable insights and predictions using healthcare big data or applying machine learning to error-prone tasks in the physician’s work flow to increase patient safety. This year, as I have in years past, I wonder how many of these predicted innovations will materially impact the day-to-day lives of practicing physicians across the country. I have a strong sense that, in reality, most practicing physicians will not feel the impact of these technologies for some time to come. I do, however, think there are HIT trends and themes that will impact practicing physicians in meaningful ways in 2019. My central prediction for 2019 is that many HIT systems and platforms will be challenged to shift their focus from physician and healthcare team workflows to the patient. I say this because there are mounting regulatory requirements and incentives that now truly place engaged patients in the center of the clinical endeavor. Take, for example, the recent requirement for hospitals to provide patients full access to the pricing of their care and the now prevalent expectation that patients should be able to access their actual care notes and charts on demand—these are going to challenge healthcare organizations and their HIT systems to the core. This call for transparency clearly exposes the complexities and idiosyncrasies of healthcare billing and pricing, and the lack of clear industry standards. In reality, very few systems natively produce information understandable to the average patient. I predict this requirement will generate tectonic shifts in the way pricing and costs are set, documented, and shared with patients.