In December 2016, the 21st Century Cures Act was signed into law, making national headlines for creating new programs and advancing regulatory reforms to speed the development and approval of new drugs and medical devices. Other provisions in the bipartisan law sought to address the opioid crisis, support precision medicine, and increase access to behavioral health services. Still, the most important part of the Cures Act for the health IT industry and most healthcare providers focused on advancing health data interoperability through a combination of new and/or revised programs, mandates, and rules. Given the importance of these provisions and since it has now been over five years since the law was enacted, let’s check in on the status of the key health IT provisions of the 21st Century Cures Act. The Cures Act tasked the U.S. Department of Health and Human Services’ (HHS) Office of the National Coordinator for Health Information Technology (ONC) with writing the new health IT regulations. ONC took its first shot at doing so by issuing a proposed rule in 2019. Then, following an extended public comment period, in March 2020 ONC released a 1,244-page final rule aptly titled, “21st Century Cures Act: Interoperability, Information Blocking, and the ONC Health IT Certification Program.” The ONC regulation established compliance or implementation deadlines for most of the rule’s major provisions at six, 24, and 36 months from the rule’s initial effective date (June 30, 2020). However, ONC later delayed most of those deadlines in response to the COVID-19 pandemic.