Interoperability in healthcare refers to the ability of different IT systems and software applications to communicate, exchange data, and use the information effectively. This includes EHR systems, patient data sharing between practices, and secure transmission of health information across the healthcare ecosystem. The article also discusses TEFCA, major interoperability standards such as HL7, FHIR, and DICOM, and the importance of secure, seamless data exchange to improve patient care and provider efficiency.